Nature Communications (Mar 2021)

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

  • Soojin Kim,
  • Yvette C. Wong,
  • Fanding Gao,
  • Dimitri Krainc

DOI
https://doi.org/10.1038/s41467-021-22113-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.