Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

H. M. Adnan Hameed; H. M. Adnan Hameed; Md Mahmudul Islam; Md Mahmudul Islam; Chiranjibi Chhotaray; Chiranjibi Chhotaray; Changwei Wang; Yang Liu; Yang Liu; Yaoju Tan; Xinjie Li; Shouyong Tan; Vincent Delorme; Wing W. Yew; Jianxiong Liu; Tianyu Zhang; Tianyu Zhang

doi:10.3389/fcimb.2018.00114

Frontiers in Cellular and Infection Microbiology (Apr 2018)

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

H. M. Adnan Hameed,
H. M. Adnan Hameed,
Md Mahmudul Islam,
Md Mahmudul Islam,
Chiranjibi Chhotaray,
Chiranjibi Chhotaray,
Changwei Wang,
Yang Liu,
Yang Liu,
Yaoju Tan,
Xinjie Li,
Shouyong Tan,
Vincent Delorme,
Wing W. Yew,
Jianxiong Liu,
Tianyu Zhang,
Tianyu Zhang

Affiliations

H. M. Adnan Hameed: State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
H. M. Adnan Hameed: University of Chinese Academy of Sciences, Beijing, China
Md Mahmudul Islam: State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Md Mahmudul Islam: University of Chinese Academy of Sciences, Beijing, China
Chiranjibi Chhotaray: State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Chiranjibi Chhotaray: University of Chinese Academy of Sciences, Beijing, China
Changwei Wang: State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Yang Liu: State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Yang Liu: Institute of Health Sciences, Anhui University, Hefei, China
Yaoju Tan: State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, China
Xinjie Li: State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, China
Shouyong Tan: State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, China
Vincent Delorme: Tuberculosis Research Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea
Wing W. Yew: Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China
Jianxiong Liu: State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, China
Tianyu Zhang: State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Tianyu Zhang: University of Chinese Academy of Sciences, Beijing, China

DOI: https://doi.org/10.3389/fcimb.2018.00114
Journal volume & issue: Vol. 8

Abstract

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Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis. Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones. Recent advances in the understanding of the molecular/ genetic basis of drug targets and drug resistance mechanisms have been steadily made. Intriguing findings through whole genome sequencing and other molecular approaches facilitate the further understanding of biology and pathology of M. tuberculosis for the development of new therapeutics to meet the immense challenge of global health.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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