Gauging the safety and efficacy of nitroglycerine used transdermally as a tocolytic agent in females with preterm labor

Abstract

Background: Preterm labor is the primary challenge in prenatal health care, leading to a high rate of mortality. As a result, in pregnant women with preterm labor, we use nitroglycerine transdermally as a tocolytic agent. The main objective of this study was to determine the best effective tocolytic agents for preterm laboring ladies to optimize their benefits. Thus, the purpose of the present study was to analyze the impact of using nitroglycerin dermal patch as a tocolytic for the management of preterm labor and to assess its side effects. Methodology: A prospective study was conducted in the Department of Obstetrics and Gynecology, ACPM Medical College, Dhule. The study was done 6 months from January 2022 to June 2022. Fifty women were enrolled in the study after informed written consent. Nulliparous and multiparous pregnancies with a gestation age of between 24 and 34 weeks were considered in the inclusion criteria, while women in active labor were excluded from the study. Results: In the present study, treatment of women with preterm labor, where transdermally used nitroglycerine patch, was found successful in 78% of women with preterm labor, while in 22% of women, results were not achieved. Conclusion: In our study, nitroglycerine patch proved to be the drug of choice for acute uterine relaxation in women with preterm labor. This prospective study supports that the transdermal patch of nitroglycerine may be a promising, safe, effective, cost-effective, and noninvasive method of tocolysis.

Keywords

• nitroglycerine
• pregnancy
• tocolytic agent