Safety and Efficacy of Cryoballoon Pulmonary Vein Isolation and Left Atrial Appendage Closure Combined Procedure and Half-Dose Rivaroxaban After Operation in Elderly Patients with Atrial Fibrillation

Abstract

Xiaogang Zhang,* Zhongying Xing,* Chao Fang, Meiling Yang, Jun Luo, Zhongping Ning Department of Cardiology, Shanghai Pudong New Area Zhoupu Hospital (Shanghai Health Medical College Affiliated Zhoupu Hospital), Shanghai, 201318, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhongping Ning, Department of Cardiology, Shanghai Pudong New Area Zhoupu Hospital (Shanghai Health Medical College Affiliated Zhoupu Hospital), No. 1500 Zhouyuan Road, Pudong New District, Shanghai, 201318, People’s Republic of China, Tel [phone], Email [email protected]: To investigate the safety and effectiveness of cryo-balloon pulmonary vein isolation (PVI) and left atrial appendage closure (LAAC) combined procedure and half-dose rivaroxaban after operation in elderly patients with atrial fibrillation (AF).Patients and Methods: A total of 203 AF patients presented for cryo-balloon PVI, and LAAC combined procedure was included from 2019 to 2021. Postoperative patients were anticoagulated with rivaroxaban with/without clopidogrel for 60 days, with oral rivaroxaban of 10 mg in the elderly group and 20 mg in the non-elderly group. Patients with AF ≥ 80 and 0.05).Conclusion: This study suggests that cryo-balloon PVI and LAAC combined procedure and half-dose rivaroxaban after the operation is safe and effective in treating elderly patients with AF.Keywords: pulmonary vein isolation, left atrial appendage closure, cryo-balloon, rivaroxaban, atrial fibrillation, elderly patients

Keywords

• pulmonary vein isolation
• left atrial appendage closure
• cryo-balloon
• rivaroxaban
• atrial fibrillation
• elderly patients