RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates

Marina Garcia-Jove Navarro; Shunnichi Kashida; Racha Chouaib; Sylvie Souquere; Gérard Pierron; Dominique Weil; Zoher Gueroui

doi:10.1038/s41467-019-11241-6

Nature Communications (Jul 2019)

RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates

Marina Garcia-Jove Navarro,
Shunnichi Kashida,
Racha Chouaib,
Sylvie Souquere,
Gérard Pierron,
Dominique Weil,
Zoher Gueroui

Affiliations

Marina Garcia-Jove Navarro: PASTEUR, Department of Chemistry, École Normale Supérieure, PSL University, Sorbonne Université, CNRS
Shunnichi Kashida: PASTEUR, Department of Chemistry, École Normale Supérieure, PSL University, Sorbonne Université, CNRS
Racha Chouaib: Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Laboratoire de Biologie du Développement
Sylvie Souquere: CNRS UMR-9196, Institut Gustave Roussy
Gérard Pierron: CNRS UMR-9196, Institut Gustave Roussy
Dominique Weil: Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Laboratoire de Biologie du Développement
Zoher Gueroui: PASTEUR, Department of Chemistry, École Normale Supérieure, PSL University, Sorbonne Université, CNRS

DOI: https://doi.org/10.1038/s41467-019-11241-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

RNA promotes liquid-liquid phase separation and contributes to the ribonucleoprotein granule assembly. Here the authors employ the protein scaffold ArtiGranule and show the role of intracellular RNA in nucleation and sizing of the phase separated condensates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal