Effects of ultrasound-mediated transdermal drug delivery in the treatment of opioid-related constipation (超声介导下药透疗法治疗阿片类药物相关性便秘的临床研究)

Abstract

Objective To investigate the effect of ultrasound-mediated transdermal drug delivery in the treatment of opioid-related constipation. Methods Totally 60 cancer patients with opioid-related constipation were randomly divided into the control group and observation group, with 30 cases in each group. All patients were treatment with lactulose oral liquid medication (15mg per time, 3 times in a day), and those in the observation group were given a-week-course of ultrasound-mediated transdermal drug delivery therapy (30 minutes per time, once a day). The treatment efficacy was measured and compared between two groups. Results The overall effective rate of the observation group was higher than that of the control group (76. 67% vs. 43. 33%, P＜0. 05). Conclusion The ultrasound-mediated drug delivery is effective in the treatment of opioid-related constipation. (目的 观察超声介导下药透疗法治疗阿片类药物相关性便秘的临床效果。方法 将60例服用阿片类药物所致便秘的癌症患者采用随机数字表法分为对照组和观察组, 每组30例。两组患者均按医嘱口服乳果糖口服液, 15 mg/次, 3 次/d; 观察组患者在对照组基础上采用超声介导下药透疗法, 1 次/d, 30 min/次, 1周为1个疗程。疗程结束后比较两组患者便秘缓解情况。结果 观察组总有效率76. 67%(23/30), 高于对照组的43. 33%(13/30), 差异有统计学意义(P<0. 05)。结论 超声介导下药透疗法对阿片类药物相关便秘有确切疗效。)

Keywords

• ultrasound-mediated
• drug delivery
• opioid drug
• constipation
• 超声介导
• 药透疗法
• 阿片类药物
• 便秘