Nature Communications (Oct 2021)

A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii

  • Zhu-Hong Li,
  • Thayer P. King,
  • Lawrence Ayong,
  • Beejan Asady,
  • Xinjiang Cai,
  • Taufiq Rahman,
  • Stephen A. Vella,
  • Isabelle Coppens,
  • Sandip Patel,
  • Silvia N. J. Moreno

DOI
https://doi.org/10.1038/s41467-021-25987-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Two-pore channels (TPCs) are cation channels that localize to acidic organelles to regulate Ca2+ dependent events. Here, Li et al. characterize a TPC from Toxoplasma gondii(TgTPC) that localizes to the apicoplast, is critical for maintaining its integrity and relevant for Ca2+ uptake from the ER through stabilizing inter-organelle contact.