Nature Communications (Jun 2017)
Type-2 innate lymphoid cells control the development of atherosclerosis in mice
- Stephen A. Newland,
- Sarajo Mohanta,
- Marc Clément,
- Soraya Taleb,
- Jennifer A. Walker,
- Meritxell Nus,
- Andrew P. Sage,
- Changjun Yin,
- Desheng Hu,
- Lauren L. Kitt,
- Alison J. Finigan,
- Hans-Reimer Rodewald,
- Christoph J. Binder,
- Andrew N. J. McKenzie,
- Andreas J. Habenicht,
- Ziad Mallat
Affiliations
- Stephen A. Newland
- Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge
- Sarajo Mohanta
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU)
- Marc Clément
- Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge
- Soraya Taleb
- Institut National de la Santé et de la Recherche Médicale
- Jennifer A. Walker
- Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology
- Meritxell Nus
- Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge
- Andrew P. Sage
- Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge
- Changjun Yin
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU)
- Desheng Hu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University
- Lauren L. Kitt
- Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge
- Alison J. Finigan
- Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge
- Hans-Reimer Rodewald
- Division of Cellular Immunology, German Cancer Research Center
- Christoph J. Binder
- Department of Laboratory Medicine, Medical University of Vienna and Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences
- Andrew N. J. McKenzie
- Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology
- Andreas J. Habenicht
- Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU)
- Ziad Mallat
- Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge
- DOI
- https://doi.org/10.1038/ncomms15781
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Type-2 innate lymphoid cells (ILC2) affect adipose tissue metabolism and function. Here the authors show that the ILC2 are present in para-aortic adipose tissue and represent a major source of IL-5 and IL-13 required for mounting atheroprotective immunity, which can be altered by high fat diet.
