Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

Jingxian Li; Yuan Xie; Shaleeka Cornelius; Xian Jiang; Richard Sando; Szymon P. Kordon; Man Pan; Katherine Leon; Thomas C. Südhof; Minglei Zhao; Demet Araç

doi:10.1038/s41467-020-16029-7

Nature Communications (May 2020)

Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

Jingxian Li,
Yuan Xie,
Shaleeka Cornelius,
Xian Jiang,
Richard Sando,
Szymon P. Kordon,
Man Pan,
Katherine Leon,
Thomas C. Südhof,
Minglei Zhao,
Demet Araç

Affiliations

Jingxian Li: Department of Biochemistry and Molecular Biology, The University of Chicago
Yuan Xie: Department of Biochemistry and Molecular Biology, The University of Chicago
Shaleeka Cornelius: Department of Molecular and Cellular Physiology, Stanford University
Xian Jiang: Department of Molecular and Cellular Physiology, Stanford University
Richard Sando: Department of Molecular and Cellular Physiology, Stanford University
Szymon P. Kordon: Department of Biochemistry and Molecular Biology, The University of Chicago
Man Pan: Department of Biochemistry and Molecular Biology, The University of Chicago
Katherine Leon: Department of Biochemistry and Molecular Biology, The University of Chicago
Thomas C. Südhof: Department of Molecular and Cellular Physiology, Stanford University
Minglei Zhao: Department of Biochemistry and Molecular Biology, The University of Chicago
Demet Araç: Department of Biochemistry and Molecular Biology, The University of Chicago

DOI: https://doi.org/10.1038/s41467-020-16029-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs) promotes excitatory synapse formation. Here authors report the high resolution cryo-EM structure of the TEN2-LPHN3 complex, describe the trimeric TEN2-LPHN3-FLRT3 complex and show how alternative-splicing regulates the TEN2-LPHN3 interaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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