The effect of rocuronium and sugammadex on progesterone levels in pregnant rabbits under general anesthesia

Abstract

The purpose of this study was to investigate the effect of rocuronium and sugammadex on progesterone (P4) levels in pregnant rabbits under general anesthesia. Twenty-one pregnant New Zealand rabbits were used in the study. After the rabbits were divided into three groups of three (Control, Group I and Group II), each animal was given 0.5 mg/kg midazolam and 6 mg/kg propofol and then put under general anesthesia with sevoflurane on the 21st day of pregnancy. No procedure was performed on the control group apart from anesthesia. Rocuronium was administered to GI at the onset of anesthesia, and in GII, sugammadex was administered 60 min after general anesthesia + rocuronium. All of the rabbits were monitored during the anesthesia procedure. A sample of venous blood was taken and biochemically analyzed to test P4 levels. The administration of rocuronium was determined to have caused an increase in the serum progesterone level in all recorded min. Sugammadex was found to cause a quantitative decrease in the level of progesterone. In conclusion, it was found out that rocuronium and sugammadex administration did not have a negative effect on progesterone levels in pregnant rabbits receiving general anesthesia.

Keywords

• pregnant
• progesterone level
• rabbit
• sugammadex
• rocuronium