Nature Communications (Aug 2021)
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
- Pan Pan,
- Miaomiao Shen,
- Zhenyang Yu,
- Weiwei Ge,
- Keli Chen,
- Mingfu Tian,
- Feng Xiao,
- Zhenwei Wang,
- Jun Wang,
- Yaling Jia,
- Wenbiao Wang,
- Pin Wan,
- Jing Zhang,
- Weijie Chen,
- Zhiwei Lei,
- Xin Chen,
- Zhen Luo,
- Qiwei Zhang,
- Meng Xu,
- Geng Li,
- Yongkui Li,
- Jianguo Wu
Affiliations
- Pan Pan
- The First Affiliated Hospital of Jinan University
- Miaomiao Shen
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Zhenyang Yu
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Weiwei Ge
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Keli Chen
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Mingfu Tian
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Feng Xiao
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Zhenwei Wang
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Jun Wang
- The Affiliated ShunDe Hospital of Jinan University
- Yaling Jia
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Wenbiao Wang
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Pin Wan
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Jing Zhang
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Weijie Chen
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Zhiwei Lei
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Xin Chen
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Zhen Luo
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Qiwei Zhang
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Meng Xu
- The First Affiliated Hospital of Jinan University
- Geng Li
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Yongkui Li
- Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University
- Jianguo Wu
- The First Affiliated Hospital of Jinan University
- DOI
- https://doi.org/10.1038/s41467-021-25015-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
SARS-CoV-2 infection has been shown to drive NLRP3 inflammasome activation and thereby cytokine storm, but how it does so is unclear. Here the authors show that the viral N protein can bind to NLRP3, resulting in enhanced interaction with ASC and thereby with the NLRP3 inflammasome.
