Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Sohei Harada; Kotaro Aoki; Koh Okamoto; Osamu Kinoshita; Kan Nawata; Yoshikazu Ishii; Kazuhiro Tateda; Masakazu Sasaki; Tomoo Saga; Yohei Doi; Hiroshi Yotsuyanagi; Kyoji Moriya; Minoru Ono

International Journal of Infectious Diseases (Jul 2019)

Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Sohei Harada,
Kotaro Aoki,
Koh Okamoto,
Osamu Kinoshita,
Kan Nawata,
Yoshikazu Ishii,
Kazuhiro Tateda,
Masakazu Sasaki,
Tomoo Saga,
Yohei Doi,
Hiroshi Yotsuyanagi,
Kyoji Moriya,
Minoru Ono

Affiliations

Sohei Harada: Department of Infectious Diseases, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Corresponding author at: Department of Infectious Diseases, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Kotaro Aoki: Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Koh Okamoto: Department of Infectious Diseases, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Osamu Kinoshita: Department of Cardiac Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Kan Nawata: Department of Cardiac Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Yoshikazu Ishii: Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Kazuhiro Tateda: Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan
Masakazu Sasaki: Department of Clinical Laboratories, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan
Tomoo Saga: Central Laboratory Division, Akita University Hospital, 1-1-1 Hondo, Akita 010-8543, Japan
Yohei Doi: Department of Infectious Diseases, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
Hiroshi Yotsuyanagi: Department of Infectious Diseases, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Kyoji Moriya: Department of Infectious Diseases, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Minoru Ono: Department of Cardiac Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Journal volume & issue: Vol. 84
pp. 44 – 47

Abstract

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The case of a patient with left ventricular assist device (LVAD)-associated endocarditis involving multiple clones of Staphylococcus aureus is presented. Different clones with distinct colony morphology were identified from blood cultures collected on the same day and showed diverse antimicrobial resistance patterns. In addition, a difference in antimicrobial susceptibility was observed even within an identical clone recovered 400 days apart due to the loss of SCCmec for methicillin and modification of the 23S rRNA target site for linezolid during a long-term treatment course. Keywords: Staphylococcus aureus, Left ventricular assist device, Linezolid resistance, Endocarditis, Whole-genome sequencing

Published in International Journal of Infectious Diseases

ISSN: 1201-9712 (Print); 1878-3511 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://www.journals.elsevier.com/international-journal-of-infectious-diseases/

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