IgE-expressing long-lived plasma cells in persistent sensitization

Shiqiu Xiong; Shiqiu Xiong; Yang Jia; Chuanhe Liu; Chuanhe Liu

doi:10.3389/fped.2022.979012

Frontiers in Pediatrics (Dec 2022)

IgE-expressing long-lived plasma cells in persistent sensitization

Shiqiu Xiong,
Shiqiu Xiong,
Yang Jia,
Chuanhe Liu,
Chuanhe Liu

Affiliations

Shiqiu Xiong: Department of Allergy, Center for Asthma Prevention and Lung Function Laboratory, Children's Hospital of Capital Institute of Pediatrics, Beijing, China
Shiqiu Xiong: Department of Pediatrics, Graduate School of Peking Union Medical College, Beijing, China
Yang Jia: Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China
Chuanhe Liu: Department of Allergy, Center for Asthma Prevention and Lung Function Laboratory, Children's Hospital of Capital Institute of Pediatrics, Beijing, China
Chuanhe Liu: Department of Pediatrics, Graduate School of Peking Union Medical College, Beijing, China

DOI: https://doi.org/10.3389/fped.2022.979012
Journal volume & issue: Vol. 10

Abstract

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Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE+ long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE+ LLPCs have yet to be identified clearly. In this review, we summarized the generation of IgE+ PCs, discussed the prosurvival factors in the microenvironment, and reviewed the unique IgE-BCR signaling, which may bring insights into understanding the survival mechanisms of IgE+ LLPCs.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

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