Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Paolo Swuec; Francesca Lavatelli; Masayoshi Tasaki; Cristina Paissoni; Paola Rognoni; Martina Maritan; Francesca Brambilla; Paolo Milani; Pierluigi Mauri; Carlo Camilloni; Giovanni Palladini; Giampaolo Merlini; Stefano Ricagno; Martino Bolognesi

doi:10.1038/s41467-019-09133-w

Nature Communications (Mar 2019)

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Paolo Swuec,
Francesca Lavatelli,
Masayoshi Tasaki,
Cristina Paissoni,
Paola Rognoni,
Martina Maritan,
Francesca Brambilla,
Paolo Milani,
Pierluigi Mauri,
Carlo Camilloni,
Giovanni Palladini,
Giampaolo Merlini,
Stefano Ricagno,
Martino Bolognesi

Affiliations

Paolo Swuec: Dipartimento di Bioscienze, Università degli Studi di Milano
Francesca Lavatelli: Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia
Masayoshi Tasaki: Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia
Cristina Paissoni: Dipartimento di Bioscienze, Università degli Studi di Milano
Paola Rognoni: Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia
Martina Maritan: Dipartimento di Bioscienze, Università degli Studi di Milano
Francesca Brambilla: Institute for Biomedical Technologies-CNR
Paolo Milani: Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia
Pierluigi Mauri: Institute for Biomedical Technologies-CNR
Carlo Camilloni: Dipartimento di Bioscienze, Università degli Studi di Milano
Giovanni Palladini: Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia
Giampaolo Merlini: Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia
Stefano Ricagno: Dipartimento di Bioscienze, Università degli Studi di Milano
Martino Bolognesi: Dipartimento di Bioscienze, Università degli Studi di Milano

DOI: https://doi.org/10.1038/s41467-019-09133-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Immunoglobulin Light Chain Amyloidosis (AL) is the most common systemic amyloidosis occurring in Western countries. Here the authors present the 4.0 Å cryo-EM structure of light chain AL55 fibrils that were isolated from the heart of an AL systemic amyloidosis patient.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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