Nature Communications (May 2017)

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

  • Claudio Isella,
  • Francesco Brundu,
  • Sara E. Bellomo,
  • Francesco Galimi,
  • Eugenia Zanella,
  • Roberta Porporato,
  • Consalvo Petti,
  • Alessandro Fiori,
  • Francesca Orzan,
  • Rebecca Senetta,
  • Carla Boccaccio,
  • Elisa Ficarra,
  • Luigi Marchionni,
  • Livio Trusolino,
  • Enzo Medico,
  • Andrea Bertotti

DOI
https://doi.org/10.1038/ncomms15107
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Stromal cells contribute to the gene expression profiles based on which colorectal cancer (CRC) molecular subtypes are classified. Here, patient-derived xenografts enable the authors to obtain cancer cell-specific transcriptomes by excluding transcripts from murine stromal cells, based on which they define CRC intrinsic subtypes (CRIS) and evaluate their prognostic and predictive potential.