Indicators of endogenous intoxication in rats with benign hyperplasia on the background of toxic effects of ethanol

Abstract

Summary. Benign prostatic hyperplasia among urological diseases of older men occupies an important place with a tendency to increase. The most common social problem is alcohol consumption. Its toxic effects are experienced by many systems and organs, because it easily interacts with many vital processes of the body. Due to the syndrome of endogenous intoxication, we can evaluate a lot of data and get results on the course of many diseases in the level of medium mass molecules and changes in erythrocyte. The aim of the study – to learn the changes in endo­genous intoxication by the level of medium mass molecules and changes in erythrocyte index in rats with benign prostatic hyperplasia with combined action of ethanol. Materials and Methods. Experimental animals were divided into 4 groups: group 1 (control group) – rats, which were injected for 28 days with distilled water orally; group 2 – animals, which for 28 days were injected with 40 % ethanol solution at the rate of 2 ml/100 g of body weight orally once a day. In rats of group 3, the development of benign prostatic hyperplasia (BPH) was simulated by subcutaneous administration of ampoule 5 % testosterone at a dose of 0.1 mg/kg once a day for 28 days; group 4 (12 animals) the model of BPH was reproduced with additional toxic effect of 40 % ethanol solution at the rate of 2 ml/100 g of body weight orally once a day for 28 days. Results. As a result of our studies, in animals of different research groups under the conditions of experimental modeling of benign prostatic hyperplasia, it was found that there is a gradual increase in endogenous intoxication on the day 7, 14, 21 of the experiment. All markers of endogenous intoxication (EI) peaked on day 21 of the study. Conclusions. We were able to identify significant changes and disturbances of intoxication in animals under the toxic effects of ethanol, which is important for their pathogenesis

Keywords

• ethanol
• endogenous intoxication
• benign prostatic hyperplasia