Oxidant-antioxidant balance in the blood and tissues of gum of the rats with experimental gastroduodenitis

Medičnì Perspektivi. 2013;18(1):8-11


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Journal Title: Medičnì Perspektivi

ISSN: 2307-0404 (Print)

Publisher: SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"

Society/Institution: SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine"

LCC Subject Category: Medicine

Country of publisher: Ukraine

Language of fulltext: Russian, English, Ukrainian

Full-text formats available: PDF



Romanenko O.H. (SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»)


Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 9 weeks


Abstract | Full Text

To study the initial changes in the periodontal tissues in diseases of the upper gastrointestinal tract, the study of the oxidant-antioxidant balance in the gum tissue and serum of rats with experimental gastro¬duo¬denitis was conducted. Increase in MDA in homogenates of the gums and blood serum by 1,5 and 2 times, and the level of catalase by the 3,9 and 1,6 times, respectively was registered. The level of superoxide dismutase in gin¬gival tissues and serum of rats with gastroduodenitis did not changeas com¬pared to control animals. Such changes are characteristic of hypoxia state. Activation of free radical oxidation of lipids in gum homogenates is not accompanied by increased oxidative modification of proteins, which is manifested by absence of significant changes in the main marker and aldehydphenilhydrazons ketonphenilhydrazons. When malondialdehyde content in the gum tissue a blood serum of rats increases in the experiment relative intensity and compensation of antiperoxid protection is observed, leading to the formation of endogenous oxygen that keeps cells activity in hypoxic conditions. With increase of intensity of oxidative stress, obviously, decompensation of antiperoxid protection and partial loss of the barrier function by epithelial cells occurs; this increases the possibility of inflammation development in the gums.