Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum

Nan-Fu Chen; Yin-Di Su; Tsong-Long Hwang; Zuo-Jian Liao; Kuan-Hao Tsui; Zhi-Hong Wen; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/molecules22030475

Molecules (Mar 2017)

Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum

Nan-Fu Chen,
Yin-Di Su,
Tsong-Long Hwang,
Zuo-Jian Liao,
Kuan-Hao Tsui,
Zhi-Hong Wen,
Yang-Chang Wu,
Ping-Jyun Sung

Affiliations

Nan-Fu Chen: Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
Yin-Di Su: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Tsong-Long Hwang: Graduate Institute of Natural Products, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Zuo-Jian Liao: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Kuan-Hao Tsui: Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
Zhi-Hong Wen: Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University and Academia Sinica, Kaohsiung 804, Taiwan
Yang-Chang Wu: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Ping-Jyun Sung: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan

DOI: https://doi.org/10.3390/molecules22030475
Journal volume & issue: Vol. 22, no. 3
p. 475

Abstract

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Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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