Briarenols C–E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum
Nan-Fu Chen,
Yin-Di Su,
Tsong-Long Hwang,
Zuo-Jian Liao,
Kuan-Hao Tsui,
Zhi-Hong Wen,
Yang-Chang Wu,
Ping-Jyun Sung
Affiliations
Nan-Fu Chen
Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
Yin-Di Su
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Zuo-Jian Liao
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Kuan-Hao Tsui
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
Zhi-Hong Wen
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University and Academia Sinica, Kaohsiung 804, Taiwan
Yang-Chang Wu
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Ping-Jyun Sung
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Three new polyoxygenated briarane diterpenoids, briarenols C–E (1–3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).
