Nature Communications (Nov 2022)
2′–5′ oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability
- Tae Kyeong Kim,
- Sejin Jeon,
- Seonjun Park,
- Seong-Keun Sonn,
- Seungwoon Seo,
- Joowon Suh,
- Jing Jin,
- Hyae Yon Kweon,
- Sinai Kim,
- Shin Hye Moon,
- Okhee Kweon,
- Bon-Hyeock Koo,
- Nayoung Kim,
- Hae-Ock Lee,
- Young-Myeong Kim,
- Young-Joon Kim,
- Sung Ho Park,
- Goo Taeg Oh
Affiliations
- Tae Kyeong Kim
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Sejin Jeon
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Seonjun Park
- Department of Biological Sciences, Ulsan National Institute of Science & Technology (UNIST)
- Seong-Keun Sonn
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Seungwoon Seo
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Joowon Suh
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Jing Jin
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Hyae Yon Kweon
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Sinai Kim
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Shin Hye Moon
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Okhee Kweon
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- Bon-Hyeock Koo
- Department of Biological Sciences, Kangwon National University
- Nayoung Kim
- Department of Microbiology, College of Medicine, The Catholic University of Korea
- Hae-Ock Lee
- Department of Microbiology, College of Medicine, The Catholic University of Korea
- Young-Myeong Kim
- Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University
- Young-Joon Kim
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Sung Ho Park
- Department of Biological Sciences, Ulsan National Institute of Science & Technology (UNIST)
- Goo Taeg Oh
- Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University
- DOI
- https://doi.org/10.1038/s41467-022-34433-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Maintaining optimal eNOS levels is important during cardiovascular events, although little is known regarding the mechanism of eNOS protection. Here, the authors show a regulatory role of endothelial OASL1 in maintaining eNOS mRNA stability and vascular biology under atheroprone conditions.
