Nature Communications (Jul 2021)
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
- Kai Xu,
- Yiran Wang,
- Chen-Hsiang Shen,
- Yiwei Chen,
- Baoshan Zhang,
- Kevin Liu,
- Yaroslav Tsybovsky,
- Shuishu Wang,
- S. Katie Farney,
- Jason Gorman,
- Tyler Stephens,
- Raffaello Verardi,
- Yongping Yang,
- Tongqing Zhou,
- Gwo-Yu Chuang,
- Antonio Lanzavecchia,
- Luca Piccoli,
- Peter D. Kwong
Affiliations
- Kai Xu
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Yiran Wang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Chen-Hsiang Shen
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Yiwei Chen
- Institute for Research in Biomedicine, Università della Svizzera italiana
- Baoshan Zhang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kevin Liu
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Yaroslav Tsybovsky
- Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
- Shuishu Wang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- S. Katie Farney
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jason Gorman
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Tyler Stephens
- Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
- Raffaello Verardi
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Yongping Yang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Tongqing Zhou
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Gwo-Yu Chuang
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Antonio Lanzavecchia
- Institute for Research in Biomedicine, Università della Svizzera italiana
- Luca Piccoli
- Institute for Research in Biomedicine, Università della Svizzera italiana
- Peter D. Kwong
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-24291-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
RIFINs are Plasmodium surface antigens that suppress the immune response by binding inhibitory receptors such as LAIR1. Here, Xu et al. characterize the interaction between RIFIN-variable 2 domain and a LAIR1 domain and identify LAIR1-binding RIFINs in several Plasmodium species.
