Communications Biology (May 2021)
Role of hydrogen bond alternation and charge transfer states in photoactivation of the Orange Carotenoid Protein
- Igor A. Yaroshevich,
- Eugene G. Maksimov,
- Nikolai N. Sluchanko,
- Dmitry V. Zlenko,
- Alexey V. Stepanov,
- Ekaterina A. Slutskaya,
- Yury B. Slonimskiy,
- Viacheslav S. Botnarevskii,
- Alina Remeeva,
- Ivan Gushchin,
- Kirill Kovalev,
- Valentin I. Gordeliy,
- Ivan V. Shelaev,
- Fedor E. Gostev,
- Dmitry Khakhulin,
- Vladimir V. Poddubnyy,
- Timofey S. Gostev,
- Dmitry A. Cherepanov,
- Tomáš Polívka,
- Miroslav Kloz,
- Thomas Friedrich,
- Vladimir Z. Paschenko,
- Victor A. Nadtochenko,
- Andrew B. Rubin,
- Mikhail P. Kirpichnikov
Affiliations
- Igor A. Yaroshevich
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Eugene G. Maksimov
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Nikolai N. Sluchanko
- A.N. Bach Institute of Biochemistry, Federal Research Center of Biotechnology of the Russian Academy of Sciences
- Dmitry V. Zlenko
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Alexey V. Stepanov
- M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Ekaterina A. Slutskaya
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Yury B. Slonimskiy
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Viacheslav S. Botnarevskii
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Alina Remeeva
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Ivan Gushchin
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Kirill Kovalev
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Valentin I. Gordeliy
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Ivan V. Shelaev
- N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
- Fedor E. Gostev
- N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
- Dmitry Khakhulin
- European XFEL GmbH
- Vladimir V. Poddubnyy
- Chemistry department, M.V. Lomonosov Moscow State University
- Timofey S. Gostev
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Dmitry A. Cherepanov
- N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
- Tomáš Polívka
- Institute of Physics, Faculty of Science, University of South Bohemia
- Miroslav Kloz
- ELI-Beamlines, Institute of Physics
- Thomas Friedrich
- Technische Universität Berlin, Institute of Chemistry PC14
- Vladimir Z. Paschenko
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Victor A. Nadtochenko
- N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
- Andrew B. Rubin
- Faculty of Biology, M.V. Lomonosov Moscow State University
- Mikhail P. Kirpichnikov
- Faculty of Biology, M.V. Lomonosov Moscow State University
- DOI
- https://doi.org/10.1038/s42003-021-02022-3
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Yaroshevich et al. present a chemical reaction mechanism of a 35-kDa blue light-triggered photoreceptor, the Orange Carotenoid Protein (OCP). They find that photoactivation critically involves the transient formation of a protonated ketocarotenoid (oxocarbenium cation) state. This study suggests the role of charge-transfer states during OCP photoconversion.
