Nature Communications (Nov 2018)

Inflammation-induced Id2 promotes plasticity in regulatory T cells

  • Sung-Min Hwang,
  • Garima Sharma,
  • Ravi Verma,
  • Seohyun Byun,
  • Dipayan Rudra,
  • Sin-Hyeog Im

DOI
https://doi.org/10.1038/s41467-018-07254-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability.