Building a Chinese pan-genome of 486 individuals

Qiuhui Li; Shilin Tian; Bin Yan; Chi Man Liu; Tak-Wah Lam; Ruiqiang Li; Ruibang Luo

doi:10.1038/s42003-021-02556-6

Communications Biology (Aug 2021)

Building a Chinese pan-genome of 486 individuals

Qiuhui Li,
Shilin Tian,
Bin Yan,
Chi Man Liu,
Tak-Wah Lam,
Ruiqiang Li,
Ruibang Luo

Affiliations

Qiuhui Li: Department of Computer Science, The University of Hong Kong
Shilin Tian: Novogene Bioinformatics Institute
Bin Yan: Department of Computer Science, The University of Hong Kong
Chi Man Liu: Department of Computer Science, The University of Hong Kong
Tak-Wah Lam: Department of Computer Science, The University of Hong Kong
Ruiqiang Li: Novogene Bioinformatics Institute
Ruibang Luo: Department of Computer Science, The University of Hong Kong

DOI: https://doi.org/10.1038/s42003-021-02556-6
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Qiuhui Li et al. report a pan-genome sequence study in Han Chinese genomes. They find 276 Mbp of DNA sequences (absent in the current human reference), and report that 46.646 Mbp common sequences improved the accuracy of variant calling and mapping rate when added to the reference genome.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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