Türk Kardiyoloji Derneği Arşivi (Jun 2016)

Evaluation of heart rate variability in patients with coronary artery ectasia and coronary artery disease

  • Bekir Serhat Yıldız,
  • Emel Ozkan,
  • Fatma Esin,
  • Hayrettin Ozkan,
  • Yusuf Izzettin Alihanoglu,
  • Ismail Dogu Kilic,
  • Harun Evrengul,
  • Havane Asuman Kaftan

DOI
https://doi.org/10.5543/tkda.2015.84899
Journal volume & issue
Vol. 44, no. 4
pp. 306 – 314

Abstract

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Objective: The present study compared heart rate variability (HRV) parameters in patients with coronary artery ectasia (CAE) and coronary artery disease (CAD). Methods: The study population consisted of 60 consecutive patients with CAE (14 women; mean age 51.63+-7.44 years), 60 consecutive patients with CA (15 women; mean age 53.67+-9.31 years), and 59 healthy individuals (13 women; mean age 52.85+-8.19 years). Electrocardiograms, 24-hour Holter analyses, and routine biochemical tests were performed, and clinical characteristics were evaluated. Coronary angiography images were analyzed. Time-domain HRV parameters, including the standard deviation (SD) of normal-to-normal intervals (SDNN) and the root mean square of difference in successive normal-tonormal intervals (RMSSD) were evaluated, as were frequencydomain HRV parameters including low-frequency (LF), very lowfrequency (VLF), high-frequency (HF), the proportion derived by dividing low- and high-frequency (LF/HF), and total power (TP). Results: SDNN was lower in both the CAE and CAD groups, compared to the healthy group (140.85+-44.21, 96.51+-31.28, and 181.05+-48.67, respectively). A significant difference in RMSSD values among the groups was determined (p=0.004). Significantly decreased VLF and HF values were found in the CAE group, compared with the healthy group (VLF p<0.001; HF, p=0.007). TP, VLF, and HF values were significantly lower (p<0.001, p<0.001, and p<0.001, respectively), but LF and LF/ HF values were significantly higher (p<0.001 for both) in the CAD group than in the healthy group. TP values were significantly higher (p<0.001), and LF and LF/HF values were lower in the CAE group, compared with the CAD group (p<0.001 for both). Conclusion: A decrease in vagal modulation or an increase in sympathetic activity of cardiac function, assessed by HRV analysis, is worse in patients with CAD than in patients with CAE.

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