SIGNIFICANCE OF СD4+ Т-LYMPHOCYTE POPULATIONS MONITORING FOR DIAGNOSING AND FORECASTING OF ORGANISM REACTION ON TRANSPLANT

Abstract

In this review article the necessity of adaptation and introduction into clinical practice of simultaneous monitoring of immune blood cells and cytokines in patients with grafted organs for a choice of individual tactic of immuno- suppressive therapy, determination of its efficiency and forecasting is proved. It is emphasized, that with the spe- cial attention it ought to concern to characteristic of CD4 + T-lymphocytes and to definition of an interrelation of their separate populations in peripheral blood (Treg, Th17, Tact memory cells – CD4+CD25hiCD127hiCD45RO) since they are the basic participants of immune system reaction on grafts.

Keywords

• allograft rejection, transplant immunology, treg, th17, cd4+-activated effecter memory cells.