Genetic diversity of penicillin-resistant Streptococcus pneumoniae

Abstract

Fifty five Streptococcus pneumoniae isolates with reduced susceptibility to penicillin, obtained from patients with respiratory tract infections during 2003 –2007, were analyzed by MLST. Ten isolates were identified by MLST as Streptococcus «viridians» group. Among the remaining isolates 33,3% (n=15) belonged to global clonal complex CC81 and demonstrated reduced susceptibility to macrolides, tetracyclynes and chloramphenicol, three isolates were additionally resistant to levofloxacin. Clonal complex CC271 was represented by 5 isolated (11,1%), CC315 – by 4 (8,9%), CC315 – by 3 (6,7%), CC156, CC280 and CC1012 were represented by 2 (4,4%) isolates each. Isolates of clonal complexes 271 and 315 demonstrated high level of associated resistance to macrolides. Twelve clonal complexes were represented by single isolates. More than 50% of isolates with reduced susceptibility to penicillin belonged to three global clonal complexes. Probably these clonal complexes were imported to Russia from other geographical regions.

Keywords

• streptococcus pneumoniae
• multilocus sequence typing