Postnatal morphology of hematoencephalic barrier in hypoxic lesion

Abstract

In infants with perinatal hypoxic lesion of the central nervous system swelling and death of the endothelium, thickening of the capillary basement membranes, karyorrhexis and plasmorrhexis of astrocytes are observed. The severity and degree of pathological changes depends on the time of hypoxic exposure (antenatal or intrapartum period) and the term of postnatal life.

Keywords

• intranatal asphyxia
• chronic intrauterine hypoxia
• blood-brain barrier
• newborn