Comparison of the aetiology, microbiological isolates and antibiotic susceptibilities of endophthalmitis between children and adults in southern China: a retrospective, cohort study
Xiaohu Ding,
Yao Yang,
Fang Duan,
Xiaofeng Lin,
Yujie Li,
Jiaqi Lin,
Manli Liu,
Jieting Zeng
Affiliations
Xiaohu Ding
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Yao Yang
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Fang Duan
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Xiaofeng Lin
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Yujie Li
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Jiaqi Lin
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Manli Liu
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Jieting Zeng
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of ophthalmology Ⅴisual Science, Guangzhou, Guangdong, China
Objectives To compare aetiology, microbiological isolates and antibiotic susceptibilities of endophthalmitis between children and adults.Design Retrospective observational study.Participants Patients admitted to Zhongshan Ophthalmic Center between January 2013 and December 2019 with clinically diagnosed endophthalmitis were included.Outcome measures The aetiology, microbiological isolates and antibiotic susceptibilities of endophthalmitis were analysed.Results Of 1803 patients, 430 (23.8%) were aged ≤16 years. In both children and adults, the main aetiology was trauma (85.6% vs 64.7%, p<0.05). Streptococcus species (spp.) (28.8%) were most prevalent in paediatric post-traumatic endophthalmitis; whereas, coagulase-negative staphylococci (36.9%) were dominant in adults. In postoperative endophthalmitis, all children had bacterial infections, while fungal infections accounted for 12.5% in adults. In endogenous endophthalmitis caused by fungi, Candida was most prevalent in adults (26.9%); whereas, all causative fungi involved filamentous fungi in children. Isolated bacteria in children presented a higher susceptibility in 7 of 11 antibiotics compared with those in adults. Levofloxacin had the highest susceptibility rate in children (97.9%), and ofloxacin had the highest susceptibility rate in adults (90.6%).Conclusion The main aetiology was trauma, with a higher proportion in children than in adults. The microbial profile of paediatric endophthalmitis was different from those of adults. Susceptibilities of causative bacteria to most antibiotics were higher in children than in adults.
