Frontiers in Cellular and Infection Microbiology (Jul 2022)

Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury

  • Jingyi Chen,
  • Yu Wang,
  • Yongxia Shi,
  • Yongpan Liu,
  • Chengyi Wu,
  • Yanrong Luo

DOI
https://doi.org/10.3389/fcimb.2022.962782
Journal volume & issue
Vol. 12

Abstract

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Intestinal ischemia/reperfusion (II/R) is a common acute and critical condition in clinical practice with a high mortality rate. However, there is still a lack of effective prevention and treatment measures for II/R injury. The role of the gut microbiota in II/R has attracted widespread attention. Recent evidence has demonstrated that the gut microbiota plays a pivotal role in the occurrence, development, and prognosis of II/R. Therefore, maintaining the homeostasis of gut microbiota and its metabolites may be a potential strategy for the treatment of II/R. This review focuses on the importance of crosstalk between the gastrointestinal ecosystem and II/R to highlight II/R-induced gut microbiota signatures and potential applications of microbial-based therapies in II/R. This will also provide potentially effective biomarkers for the prediction, diagnosis and treatment of II/R.

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