Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis

Abstract

Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (1–4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1–4 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.

Keywords

• Junceella fragilis
• 8-hydroxybriarane
• frajunolides
• anti-inflammatory activities