Study of Kinetics of degradation of cefuroxime axetil in acetone solution

Abstract

In order to study the stability of cefuroxime axetil acetone solution, by using high-performance liquid chromatography, the single factor test was conducted to study the variation ofcefuroxime axetilcontent in the solution with time under different conditions such as the initial solution pH, temperature and oxidant species. The chemical reaction kinetics method was used to establish the degradation reaction kinetics models of cefuroxime axetil under different conditions. The model parameters were obtained by regression, and the half-life(t1/2) was predicted. The degradation mechanism of cefuroxime axetil was analyzed from the molecular scale by Materials Studio simulation software. The results show that the degradation of cefuroxime axetil acetone solution under the above conditions is in line with the first-order reaction kinetics. When pH is lower than 9.54, cefuroxime axetil acetone solution is basically stable. When pH is higher than 9.54, the chemical stability of cefuroxime axetil acetone solution becomes worse, the degradation rate increases rapidly, and the color of the solution becomes darker with the increase of pH value. The chemical stability of cefuroxime axetil acetone solution decreases with the increase of temperature. The research result provides data support for production process, crystallization process design, storage and application.

Keywords

• chemical kinetics; hplc; cefuroxime axetil; stability; degradation