Nature Communications (Mar 2019)
Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
- Ei-Wen Yang,
- Jae Hoon Bahn,
- Esther Yun-Hua Hsiao,
- Boon Xin Tan,
- Yiwei Sun,
- Ting Fu,
- Bo Zhou,
- Eric L. Van Nostrand,
- Gabriel A. Pratt,
- Peter Freese,
- Xintao Wei,
- Giovanni Quinones-Valdez,
- Alexander E. Urban,
- Brenton R. Graveley,
- Christopher B. Burge,
- Gene W. Yeo,
- Xinshu Xiao
Affiliations
- Ei-Wen Yang
- Department of Integrative Biology and Physiology, UCLA
- Jae Hoon Bahn
- Department of Integrative Biology and Physiology, UCLA
- Esther Yun-Hua Hsiao
- Department of Integrative Biology and Physiology, UCLA
- Boon Xin Tan
- Department of Integrative Biology and Physiology, UCLA
- Yiwei Sun
- Department of Integrative Biology and Physiology, UCLA
- Ting Fu
- Department of Integrative Biology and Physiology, UCLA
- Bo Zhou
- Department of Psychiatry and Behavioral Sciences, Department of Genetics, Stanford University School of Medicine
- Eric L. Van Nostrand
- Department of Cellular and Molecular Medicine, UCSD
- Gabriel A. Pratt
- Department of Cellular and Molecular Medicine, UCSD
- Peter Freese
- Department of Biology, MIT
- Xintao Wei
- Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health
- Giovanni Quinones-Valdez
- Department of Bioengineering, UCLA
- Alexander E. Urban
- Department of Psychiatry and Behavioral Sciences, Department of Genetics, Stanford University School of Medicine
- Brenton R. Graveley
- Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health
- Christopher B. Burge
- Department of Biology, MIT
- Gene W. Yeo
- Department of Cellular and Molecular Medicine, UCSD
- Xinshu Xiao
- Department of Integrative Biology and Physiology, UCLA
- DOI
- https://doi.org/10.1038/s41467-019-09292-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.
