Терапевтический архив (Jul 2009)

Pilot experience in the treatment of poor-prognosis primary diffuse large-B-cell lymphosarcoma of the bones and soft tissues with a modified program NHL-BFM-90

  • Anna Konstantinovna Morozova,
  • Evgeniy Evgen'evich Zvonkov,
  • Aleksandra Mikhaylovna Kremenetskaya,
  • Aminat Umuraskhabovna Magomedova,
  • Tat'yana Nikiforovna Obukhova,
  • Vasiliy Evgen'evich Mamonov,
  • Elena Aleksandrovna Baryakh,
  • Andrey Vladimirovich Gubkin,
  • Aleksandra Ivanovna Lukina,
  • Ekaterina Alekseevna Ilyushkina,
  • Olesya Sergeevna Fink,
  • Tat'yana Nikolaevna Perestoronina,
  • Sergey Kirillovich Kravchenko,
  • A K Morosova,
  • E E Zvonkov,
  • A M Kremenetskaya,
  • A U Magomedova,
  • T N Obukhova,
  • V E Mamonov,
  • E A Baryakh,
  • A V Gubkin,
  • A I Lukina,
  • E A Ilyushkina,
  • O S Fink,
  • T N Perestoronina,
  • S K Kravchenko

Journal volume & issue
Vol. 81, no. 7
pp. 61 – 65

Abstract

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Aim. To evaluate efficacy of intensive modified program NHL-BFM-90 (mNHL-BFM-90) in adult poor-prognosis patients with diffuse large B-cell lymphosarcoma (DLBCL) of the bones and soft tissues. Material and methods. The mNHL-BFM-90 program was used in the treatment of 3 male and 2 female patients aged 17-69 years (median 42 years). Four patients had DLBCL of the bones and one patient - DLBCL of the soft tissues. All the patients had tumors more than 10 cm in size. B-symptoms, a high concentration of lactate dehydrogenase (LDG) were registered in 3 patients. One patient had stage IE by Ann-Arbor, two - stage IIE (involvement of regional lymph nodes), two - stage ME (multiple bone lesions). A total of 4-6 blocks of polychemotherapy according to mNHL-BFM-90 program were performed. Results. Complete remissions were achieved in all the patients. They had no recurrences after 6 to 20 month (median 13 months) follow-up. Conclusion. Positive results of the program mNHL-BFM-90 in poor-prognosis patients with DLBCL of the bones and tissues necessitate further studies of this therapy.

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