Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice

Christopher G. Cover; Andrew J. Kesner; Shehzad Ukani; Elliot A. Stein; Satoshi Ikemoto; Yihong Yang; Hanbing Lu

doi:10.1038/s42003-020-01612-x

Communications Biology (Jan 2021)

Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice

Christopher G. Cover,
Andrew J. Kesner,
Shehzad Ukani,
Elliot A. Stein,
Satoshi Ikemoto,
Yihong Yang,
Hanbing Lu

Affiliations

Christopher G. Cover: Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH
Andrew J. Kesner: Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH
Shehzad Ukani: Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH
Elliot A. Stein: Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH
Satoshi Ikemoto: Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH
Yihong Yang: Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH
Hanbing Lu: Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIH

DOI: https://doi.org/10.1038/s42003-020-01612-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 8

Abstract

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Cover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex. This method presents noninvasive whole brain readout for adaptive behavior of mice in response to circuit-specific neuromodulation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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