FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS

Abstract

During the chemotherapy, frequency and characteristics of adverse reactions to second line anti-tuberculosis drugs in 324 patients ill with multiple drug resistant tuberculosis were investigated. The majority of patients (319 - 98.4%) had various adverse reactions to second line anti-tuberculosis drugs.Adverse reactions caused by one or two drugs provided no negative impact on treatment efficiency. As the number of poorly tolerated drugs increased, the level of favorable treatment outcomes went down, whereby the significant confident correlation was observed between adverse outcomes and poor tolerance of 3 and more anti-tuberculosis drugs p = 0.000, r = +> 0.9. There was doubtful correlation observed between poor tolerance anti-tuberculosis drugs and cases deaths (p > 0.05, r = +> 0.3). The doubtful correlation was also observed between cases of lost from treatment and poor tolerance of anti-tuberculosis drugs, p > 0.05, r = +> 0.3.

Keywords

• множественная лекарственная устойчивость возбудителя туберкулеза
• переносимость препаратов второго ряда
• побочные реакции на противотуберкулезные препараты второго ряда