Nature Communications (Nov 2017)

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

  • Hua Liang,
  • Liufu Deng,
  • Yuzhu Hou,
  • Xiangjiao Meng,
  • Xiaona Huang,
  • Enyu Rao,
  • Wenxin Zheng,
  • Helena Mauceri,
  • Matthias Mack,
  • Meng Xu,
  • Yang-Xin Fu,
  • Ralph R. Weichselbaum

DOI
https://doi.org/10.1038/s41467-017-01566-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that the use of CCR2 antibodies in mice reduces such resistance.