Communications Biology (Mar 2023)
Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice
- Zhuoran Wang,
- Qiang Li,
- Brad J. Kolls,
- Brian Mace,
- Shu Yu,
- Xuan Li,
- Wei Liu,
- Eduardo Chaparro,
- Yuntian Shen,
- Lihong Dang,
- Ángela del Águila,
- Joshua D. Bernstock,
- Kory R. Johnson,
- Junjie Yao,
- William C. Wetsel,
- Scott D. Moore,
- Dennis A. Turner,
- Wei Yang
Affiliations
- Zhuoran Wang
- Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center
- Qiang Li
- Department of Neurology, Duke University Medical Center
- Brad J. Kolls
- Department of Neurology, Duke University Medical Center
- Brian Mace
- Department of Neurology, Duke University Medical Center
- Shu Yu
- Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center
- Xuan Li
- Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center
- Wei Liu
- Department of Bioengineering, Duke University
- Eduardo Chaparro
- Department of Neurosurgery, Duke University Medical Center
- Yuntian Shen
- Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center
- Lihong Dang
- Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center
- Ángela del Águila
- Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center
- Joshua D. Bernstock
- National Institute of Neurological Disorders and Stroke, NINDS/NIH
- Kory R. Johnson
- National Institute of Neurological Disorders and Stroke, NINDS/NIH
- Junjie Yao
- Department of Bioengineering, Duke University
- William C. Wetsel
- Department of Neurology, Duke University Medical Center
- Scott D. Moore
- Department of Psychiatry and Behavioral Sciences, Duke University Medical Center
- Dennis A. Turner
- Departments of Neurosurgery, Neurobiology and Biomedical Engineering, Duke University Medical Center
- Wei Yang
- Multidisciplinary Brain Protection Program, Department of Anesthesiology, Duke University Medical Center
- DOI
- https://doi.org/10.1038/s42003-023-04594-8
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 11
Abstract
XBP1s is a key effector of the unfolded protein response. Neuron-specific overexpression of Xbp1s in the brain leads to impaired GABAergic signaling and recurrent spontaneous seizures in mice.
