Biology of Sex Differences (Nov 2022)

RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance

  • Zuoqin Du,
  • Jiaqi Wu,
  • Ziqian Feng,
  • Xiaoyu Ma,
  • Tao Zhang,
  • Xin Shu,
  • Jin Xu,
  • Liqun Wang,
  • Mao Luo,
  • Jianbo Wu

DOI
https://doi.org/10.1186/s13293-022-00476-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 8

Abstract

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Highlights Female RAGE−/− mice showed significantly improved glucose and insulin tolerance compared to male RAGE−/− mice. Female RAGE deficiency promotes M2 macrophage polarization in adipose tissues. Female RAGE deficiency prevents oxidative stress in adipose tissues. Female RAGE deficiency protects insulin-AKT signaling in adipose tissues.

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