Nature Communications (Aug 2022)

Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti

  • Yoann Saucereau,
  • Thomas H. Wilson,
  • Matthew C. K. Tang,
  • Martin C. Moncrieffe,
  • Steven W. Hardwick,
  • Dimitri Y. Chirgadze,
  • Sandro G. Soares,
  • Maria Jose Marcaida,
  • Nicholas J. Gay,
  • Monique Gangloff

DOI
https://doi.org/10.1038/s41467-022-32690-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Aedes aegypti can act as a vector for viral pathogens but the mechanism of viral resistance and evolving host-pathogen tolerance are poorly understood. Here the authors structurally characterise a duplicated pair of interacting Toll immunoreceptors and the cytokine ligand Spaetzle1C and show their dose-dependent function and mechanism of activation.