Research on AT-Ⅲ, PAI and t-PA in patients with different stages of diabetic retinopathy

Abstract

AIM: To explore the relationship between the different stages of diabetic retinopathy and the related factors of vascular endothelial function, and to provide a theoretical basis for improving the function of vascular endothelium to find a way to delay or even inhibit the occurrence or progression of DR. METHODS:We collected during March 2015 to December 2015 in Department of Ophthalmology and endocrinology in our hospital, 178 cases of type 2 diabetes mellitus patients and 62 cases of blood specimen in health control group. According to the results of fundus fluorescence angiography(FFA), they were divided into four groups, diabetes patients without retinopathy, diabetes patients with non-proliferative diabetic retinopathy(NPDR), diabetes patients with proliferative diabetic retinopathy(PDR)and healthy control group. We detected blood samples of antithrombin Ⅲ(AT-Ⅲ), fibrinolytic enzyme activation inhibitor(PAI), the original organization type fibrinolytic enzyme activator(t-PA)index and the correlation of diabetic retinopathy in installment. RESULTS: This study showed that AT-Ⅲ was significantly different among the four groups(F=5.986, PF=7.434, PF=2.556, P>0.05); there were relations between the different stages of diabetic retinopathy and AT-Ⅲ, PAI.CONCLUSION: The degree of diabetic retinopathy has a close relationship with the content of antithrombin Ⅲ and plasminogen activator inhibitor, and it is closely related to the function of vascular endothelium.

Keywords

• diabetic retinopathy
• vascular endothelial factor
• diabetic retinopathy staging
• diabetic retinopathy staging