HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells

Sagar Mahale; Meenakshi Setia; Bharat Prajapati; Santhilal Subhash; Mukesh Pratap Yadav; Subazini Thankaswamy Kosalai; Ananya Deshpande; Jagannath Kuchlyan; Mirco Di Marco; Fredrik Westerlund; L. Marcus Wilhelmsson; Chandrasekhar Kanduri; Meena Kanduri

doi:10.1038/s41467-022-32537-0

Nature Communications (Aug 2022)

HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells

Sagar Mahale,
Meenakshi Setia,
Bharat Prajapati,
Santhilal Subhash,
Mukesh Pratap Yadav,
Subazini Thankaswamy Kosalai,
Ananya Deshpande,
Jagannath Kuchlyan,
Mirco Di Marco,
Fredrik Westerlund,
L. Marcus Wilhelmsson,
Chandrasekhar Kanduri,
Meena Kanduri

Affiliations

Sagar Mahale: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Meenakshi Setia: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Bharat Prajapati: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Santhilal Subhash: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Mukesh Pratap Yadav: Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Subazini Thankaswamy Kosalai: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Ananya Deshpande: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Jagannath Kuchlyan: Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry, Chalmers University of Technology
Mirco Di Marco: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Fredrik Westerlund: Department of Biology and Biological Engineering, Chemical Biology, Chalmers University of Technology
L. Marcus Wilhelmsson: Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry, Chalmers University of Technology
Chandrasekhar Kanduri: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Meena Kanduri: Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg

DOI: https://doi.org/10.1038/s41467-022-32537-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Using fibroblast growth factor 2 (FGF-2) induced sense and antisense transcripts IER3 and IER3-AS1 as a model system, authors highlight the role of HnRNPK in regulating double strand RNA formation in the loci with overlapping transcripts.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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