Synthesis of pyrimido[1,6-a]quinoxalines via intermolecular trapping of thermally generated acyl(quinoxalin-2-yl)ketenes by Schiff bases

Svetlana O. Kasatkina; Ekaterina E. Stepanova; Maksim V. Dmitriev; Ivan G. Mokrushin; Andrey N. Maslivets

doi:10.3762/bjoc.14.147

Beilstein Journal of Organic Chemistry (Jul 2018)

Synthesis of pyrimido[1,6-a]quinoxalines via intermolecular trapping of thermally generated acyl(quinoxalin-2-yl)ketenes by Schiff bases

Svetlana O. Kasatkina,
Ekaterina E. Stepanova,
Maksim V. Dmitriev,
Ivan G. Mokrushin,
Andrey N. Maslivets

Affiliations

Svetlana O. Kasatkina: Department of Chemistry, Perm State University, ul. Bukireva 15, Perm 614990, Russian Federation
Ekaterina E. Stepanova: Department of Chemistry, Perm State University, ul. Bukireva 15, Perm 614990, Russian Federation
Maksim V. Dmitriev: Department of Chemistry, Perm State University, ul. Bukireva 15, Perm 614990, Russian Federation
Ivan G. Mokrushin: Department of Chemistry, Perm State University, ul. Bukireva 15, Perm 614990, Russian Federation
Andrey N. Maslivets: Department of Chemistry, Perm State University, ul. Bukireva 15, Perm 614990, Russian Federation

DOI: https://doi.org/10.3762/bjoc.14.147
Journal volume & issue: Vol. 14, no. 1
pp. 1734 – 1742

Abstract

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Acyl(quinoxalin-2-yl)ketenes generated by thermal decarbonylation of 3-acylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-triones react regioselectively with Schiff bases under solvent-free conditions to form pyrimido[1,6-a]quinoxaline derivatives in good yields.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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