The choice of treatment method in patients with complicated gastrointestinal stromal tumors. Clinical observation and literature review

Abstract

Gastrointestinal stromal tumors (GISTs) can be complicated with gastrointestinal bleeding, ileus, gastrointestinal perforation at the site of tumor, spontaneous intraabdominal bleeding because of ruptured GIST and the formation of necrotic cavities in the tumor communicated with the lumens of hollow organs. Common practice in such cases is combined use of surgery with imatinib treatment. The article deals with the data of literature review concerning the incidence and clinical characteristics of complications in patients with different tumors. We showed the clinical study, where imatinib therapy was used as the first part of the treatment patients with luminal GIST of the stomach, complicated with gastric bleeding. Neoadjuvant therapy had significantly reduced tumor sizes; improved the condition of the patient and helped us to perform surgery.

Keywords

• gastrointestinal stromal tumor
• complications
• imatinib
• surgical treatment