Frontiers in Pharmacology (Feb 2025)
The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection
- Zhaoshan Zhang,
- Zhaoshan Zhang,
- Zhaoshan Zhang,
- Haichao Wang,
- Haichao Wang,
- Haichao Wang,
- Xi Kan,
- Xi Kan,
- Xi Kan,
- Xiaozhao Zhang,
- Xiaozhao Zhang,
- Xiaozhao Zhang,
- Senping Xu,
- Senping Xu,
- Senping Xu,
- Jie Cai,
- Jie Cai,
- Jie Cai,
- Jiawei Guo,
- Jiawei Guo,
- Jiawei Guo
Affiliations
- Zhaoshan Zhang
- Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China
- Zhaoshan Zhang
- Department of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, China
- Zhaoshan Zhang
- Department of Pharmacology, School of Medicine, Yangtze University, Jingzhou, China
- Haichao Wang
- Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China
- Haichao Wang
- Department of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, China
- Haichao Wang
- Department of Pharmacology, School of Medicine, Yangtze University, Jingzhou, China
- Xi Kan
- Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China
- Xi Kan
- Department of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, China
- Xi Kan
- Department of Pharmacology, School of Medicine, Yangtze University, Jingzhou, China
- Xiaozhao Zhang
- Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China
- Xiaozhao Zhang
- Department of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, China
- Xiaozhao Zhang
- Department of Pharmacology, School of Medicine, Yangtze University, Jingzhou, China
- Senping Xu
- Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China
- Senping Xu
- Department of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, China
- Senping Xu
- Department of Pharmacology, School of Medicine, Yangtze University, Jingzhou, China
- Jie Cai
- Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China
- Jie Cai
- Department of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, China
- Jie Cai
- Department of Pharmacology, School of Medicine, Yangtze University, Jingzhou, China
- Jiawei Guo
- Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China
- Jiawei Guo
- Department of Stomatology, The First Affiliated Hospital of Yangtze University, Yangtze University, Jingzhou, China
- Jiawei Guo
- Department of Pharmacology, School of Medicine, Yangtze University, Jingzhou, China
- DOI
- https://doi.org/10.3389/fphar.2025.1519273
- Journal volume & issue
-
Vol. 16
Abstract
Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between ferroptosis and AD lies in its damaging effect on vascular cells. In AD, ferroptosis worsens the damage to vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), thereby weakening the vascular wall’s structural integrity and accelerating the onset and progression of the condition. However, the molecular mechanisms through which ferroptosis regulates the onset and progression of AD remain poorly understood. This article explores the relationship between ferroptosis and AD.
Keywords
