Nature Communications (Jan 2016)
LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
- Yixuan Wang,
- Qian Wu,
- Peng Yang,
- Chenfei Wang,
- Jing Liu,
- Wenyu Ding,
- Wensu Liu,
- Ye Bai,
- Yuanyuan Yang,
- Hong Wang,
- Shaorong Gao,
- Xiaoqun Wang
Affiliations
- Yixuan Wang
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji University
- Qian Wu
- State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,
- Peng Yang
- National Institute of Biological Sciences (NIBS)
- Chenfei Wang
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji University
- Jing Liu
- State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,
- Wenyu Ding
- State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,
- Wensu Liu
- State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,
- Ye Bai
- State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,
- Yuanyuan Yang
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji University
- Hong Wang
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji University
- Shaorong Gao
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, School of Life Sciences and Technology, Tongji University
- Xiaoqun Wang
- State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing MRI Centre for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing Institute for Brain Disorders, 8803, 8th Building, 15 Datun Road, Chaoyang District,
- DOI
- https://doi.org/10.1038/ncomms10481
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Epigenetic regulation plays a key role in cortical development. Here the authors show that Rcor2, a co-repressor of the histone demethylase LSD1/KDM1A complex, regulates neural progenitor cell proliferation and cortical neurogenesis by repressing sonic hedgehog signaling.
