Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes

George Eng; Benjamin W. Lee; Lev Protas; Mark Gagliardi; Kristy Brown; Robert S. Kass; Gordon Keller; Richard B. Robinson; Gordana Vunjak-Novakovic

doi:10.1038/ncomms10312

Nature Communications (Jan 2016)

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes

George Eng,
Benjamin W. Lee,
Lev Protas,
Mark Gagliardi,
Kristy Brown,
Robert S. Kass,
Gordon Keller,
Richard B. Robinson,
Gordana Vunjak-Novakovic

Affiliations

George Eng: Department of Biomedical Engineering, Columbia University
Benjamin W. Lee: Department of Biomedical Engineering, Columbia University
Lev Protas: Department of Pharmacology, Columbia University
Mark Gagliardi: McEwen Centre for Regenerative Medicine, University Health Network
Kristy Brown: Department of Pathology and Cell Biology, Columbia University
Robert S. Kass: Department of Pharmacology, Columbia University
Gordon Keller: McEwen Centre for Regenerative Medicine, University Health Network
Richard B. Robinson: Department of Pharmacology, Columbia University
Gordana Vunjak-Novakovic: Department of Biomedical Engineering, Columbia University

DOI: https://doi.org/10.1038/ncomms10312
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The use of stem cell-derived cardiomyocytes for heart repair is hampered by their immature structural and contractile properties that may cause arrhythmia. Here, Eng et al.show that electrical conditioning of human cardiomyocytes in 3D culture can enhance connectivity and provide resistance to arrhythmia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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