Nature Communications (Mar 2022)

Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay

  • Fátima Cairrão,
  • Cristiana C. Santos,
  • Adrien Le Thomas,
  • Scot Marsters,
  • Avi Ashkenazi,
  • Pedro M. Domingos

DOI
https://doi.org/10.1038/s41467-022-29105-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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In Drosophila, ER-targeted mRNAs are degraded by Ire1-dependent pathway. Here the authors report that the fly mRNA binding protein Pumilio is phosphorylated by Ire1 and binds to Xbp1 mRNA, protecting it from the non-canonical endoribonuclease activity of Ire1.