Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Xin Ma; Xin Ma; Yi Ru; Yi Ru; Ying Luo; Ying Luo; Le Kuai; Le Kuai; Qi-Long Chen; Yun Bai; Ye-Qiang Liu; Jia Chen; Yue Luo; Jian-Kun Song; Mi Zhou; Mi Zhou; Bin Li; Bin Li

doi:10.3389/fcell.2022.942838

Frontiers in Cell and Developmental Biology (Jul 2022)

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Xin Ma,
Xin Ma,
Yi Ru,
Yi Ru,
Ying Luo,
Ying Luo,
Le Kuai,
Le Kuai,
Qi-Long Chen,
Yun Bai,
Ye-Qiang Liu,
Jia Chen,
Yue Luo,
Jian-Kun Song,
Mi Zhou,
Mi Zhou,
Bin Li,
Bin Li

Affiliations

Xin Ma: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Xin Ma: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Yi Ru: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yi Ru: Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China
Ying Luo: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Ying Luo: Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China
Le Kuai: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Le Kuai: Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China
Qi-Long Chen: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Yun Bai: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Ye-Qiang Liu: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Jia Chen: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Yue Luo: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Jian-Kun Song: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Mi Zhou: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Mi Zhou: Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China
Bin Li: Shanghai Skin Disease Hospital of Tongji University, Shanghai, China
Bin Li: Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fcell.2022.942838
Journal volume & issue: Vol. 10

Abstract

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Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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Abstract

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