Nature Communications (Sep 2017)

Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice

  • Yo Oishi,
  • Qi Xu,
  • Lu Wang,
  • Bin-Jia Zhang,
  • Koji Takahashi,
  • Yohko Takata,
  • Yan-Jia Luo,
  • Yoan Cherasse,
  • Serge N. Schiffmann,
  • Alban de Kerchove d’Exaerde,
  • Yoshihiro Urade,
  • Wei-Min Qu,
  • Zhi-Li Huang,
  • Michael Lazarus

DOI
https://doi.org/10.1038/s41467-017-00781-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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In addition to circadian and homoeostatic drives, motivational levels influence sleep−wake cycles. Here the authors demonstrate that adenosine receptor-expressing neurons in the nucleus accumbens core that project to the ventral pallidum are inhibited by motivational stimuli and are causally involved in the control of slow-wave sleep.