A review of multi-omics data integration through deep learning approaches for disease diagnosis, prognosis, and treatment

Abstract

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Accurate diagnosis is the key to providing prompt and explicit treatment and disease management. The recognized biological method for the molecular diagnosis of infectious pathogens is polymerase chain reaction (PCR). Recently, deep learning approaches are playing a vital role in accurately identifying disease-related genes for diagnosis, prognosis, and treatment. The models reduce the time and cost used by wet-lab experimental procedures. Consequently, sophisticated computational approaches have been developed to facilitate the detection of cancer, a leading cause of death globally, and other complex diseases. In this review, we systematically evaluate the recent trends in multi-omics data analysis based on deep learning techniques and their application in disease prediction. We highlight the current challenges in the field and discuss how advances in deep learning methods and their optimization for application is vital in overcoming them. Ultimately, this review promotes the development of novel deep-learning methodologies for data integration, which is essential for disease detection and treatment.

Keywords

• deep learning
• multi-omics
• data integration
• noncoding RNA
• complex disease